Regulatory evolution of innate immunity through co - option of endogenous retroviruses
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چکیده
15. S. D. Boyd et al., J. Immunol. 184, 6986–6992 (2010). 16. K. J. Jackson et al., Immunogenetics 64, 3–14 (2012). 17. A. Sanchez, S. G. Trappier, B. W. Mahy, C. J. Peters, S. T. Nichol, Proc. Natl. Acad. Sci. U.S.A. 93, 3602–3607 (1996). 18. S. K. Gire et al., Science 345, 1369–1372 (2014). 19. G. S. Mohan, W. Li, L. Ye, R. W. Compans, C. Yang, PLOS Pathog. 8, e1003065 (2012). 20. D. R. Bowley, A. F. Labrijn, M. B. Zwick, D. R. Burton, Protein Eng. Design Select. 20, 81–90 (2007). 21. J. Audet et al., Sci. Rep. 4, 6881 (2014). 22. W. Weissenhorn, A. Carfí, K. H. Lee, J. J. Skehel, D. C. Wiley, Mol. Cell 2, 605–616 (1998). 23. M. Bray, K. Davis, T. Geisbert, C. Schmaljohn, J. Huggins, J. Infect. Dis. 179, S248–S258 (1999). 24. X. Qiu et al., PLOS Negl. Trop. Dis. 6, e1575 (2012). 25. J. R. Kugelman et al., Cell Rep. 12, 2111–2120 (2015). 26. X. Qiu et al., Sci. Transl. Med. 4, 138ra81 (2012). 27. T. Hashiguchi et al., Cell 160, 904–912 (2015). 28. Y. Shen, J. Maupetit, P. Derreumaux, P. Tufféry, J. Chem. Theory Comput. 10, 4745–4758 (2014). 29. S. Lyskov et al., PLOS One 8, e63906 (2013). 30. A. Sivasubramanian, A. Sircar, S. Chaudhury, J. J. Gray, Proteins 74, 497–514 (2009).
منابع مشابه
Regulatory evolution of innate immunity through co-option of endogenous retroviruses.
Endogenous retroviruses (ERVs) are abundant in mammalian genomes and contain sequences modulating transcription. The impact of ERV propagation on the evolution of gene regulation remains poorly understood. We found that ERVs have shaped the evolution of a transcriptional network underlying the interferon (IFN) response, a major branch of innate immunity, and that lineage-specific ERVs have disp...
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The human genome comprises 8 % endogenous retroviruses (ERVs), the majority of which are defective due to deleterious mutations. Nonetheless, transcripts of ERVs are found in most tissues, and these transcripts could either be reverse transcribed to generate ssDNA or expressed to generate proteins. Thus, the expression of ERVs could produce nucleic acids or proteins with viral signatures, much ...
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